Cardiac risk
Sources:
Tim Ferriss, along with his guests, has discussed several aspects of cardiac risk in different contexts:
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Ibogaine and Cardiac Risk: Tim Ferriss and explore the cardiac risks associated with ibogaine and its metabolites. They discuss using IV magnesium to mitigate the risk of cardiac arrhythmia (torsades) observed in patients treated with ibogaine. This approach has shown promise, as there have not been any reported cases of torsades among the roughly 1,000 patients treated in Mexico, compared to some significant risks in other studies 1.
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Exploring Cardiac Safety: Tim and Nolan dig deeper into improving the safety profiles of substances like ibogaine, particularly comparing the cardiac risks with other treatments. They also raise concerns about the long-term negative cardiac effects of microdosing psychedelics, highlighting the FDA's guidance on potential cardiac valve problems due to 5-HT2B receptor stimulation 2.
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Risky Treatments: Nolan Williams discusses the risks of various treatments, such as a one in 100 risk of head bleeds with certain treatments and a one in 300 risk of torsades with ibogaine. He emphasizes the need for exploring these treatments to help people who do not respond to traditional methods like Suboxone or methadone 3.
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Ozempic Benefits: Kevin Rose shares his experience with Ozempic, a drug that aids in glucose control and reduces the risk of major cardiac events. Despite some side effects, Ozempic has demonstrated a 39% reduction in non-fatal strokes and a 26% reduction in the risk of major cardiac events, making it especially appealing for those with a family history of heart disease 4.
These discussions underscore the importance of balancing potential cardiac risks with the benefits, particularly for individuals with few other treatment options.
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