Growth Hormone Releasing Peptides

Growth Hormone Releasing Peptides (GHRP) are used to stimulate the production of growth hormone in the body. This class of peptides offers an alternative to direct growth hormone therapy, often having fewer negative impacts on endogenous hormone levels.

Types and Mechanisms of GHRP

1. GHRH-like Peptides:

   • Semirellin, Tesamorelin, and CJC 1295: These peptides mimic the natural growth hormone-releasing hormone, promoting the release of growth hormone without strongly affecting prolactin or cortisol levels 1 2.

2. Ghrelin Mimetics:

   • Ipamorelin, Ibutamorin (MK-677): These act on the ghrelin receptor to increase growth hormone levels. They can also increase hunger and, in some cases, anxiety 1 2.

3. Hexarelin and GHRPs (like GHRP-2, -3, -6):

   • Hexarelin: Known for inducing high pulses of growth hormone but can lead to desensitization of growth hormone receptors and increase prolactin and cortisol levels 1 2.

Effects and Side Effects

• Increased Growth Hormone and IGF-1: These peptides promote the release of growth hormone and subsequently insulin-like growth factor 1 (IGF-1), supporting muscle growth, fat loss, and potentially rejuvenation effects 2.
• Prolactin and Cortisol: Some peptides like Ibutamorin and the GHRP series can increase cortisol and prolactin, potentially causing side effects like increased appetite, anxiety, or hormone imbalances 1.
• Insulin Sensitivity: The use of peptides such as Tesamorelin has shown benefits in improving insulin sensitivity, particularly in patients with excess visceral fat, by enhancing the body's use of fat for energy 3.
  • 

    1

    Growth Hormone Peptides

    00:58:39
    
  • 

    2

    Growth Hormone Peptides

    00:53:40
    
  • 

    3

    Growth Hormone Insights

    00:16:13
    
  • 

    4

    Growth Hormone Peptides

    00:56:31
    
  • 

    5

    Growth Hormone Peptides

    00:19:56
    

Usage and Precautions

• Proper Guidance: It's crucial to work with a knowledgeable physician to ensure appropriate dosages and combinations, avoiding side effects like hormonal imbalances or receptor desensitization 4.
• Timing: These peptides are usually taken before bed on an empty stomach to maximize their effectiveness in stimulating nighttime growth hormone release 4.

Insights and Recommendations

Experts like Andrew Huberman and Jay Campbell emphasize the importance of sourcing these peptides from reliable pharmacies and being cautious with their usage. Combining different peptides requires understanding their mechanisms to avoid redundant pathways and adverse side effects 1 5.

Overall, while GHRP can be effective tools for increasing growth hormone, their application should be carefully managed to balance benefits and risks.