Diet Study Transparency
Spencer discusses the importance of transparency in a diet study, aiming to monitor the effects of severe hypercholesterolemia over a year. The challenges of study design without a comparison group and the need to consider normal atherosclerosis progression are highlighted.In this clip
From this podcast

The Proof with Simon Hill
Cholesterol, Keto Diets, and Heart Disease | Dr Spencer Nadolsky
Related Questions
I'm a 32-year-old reasonably healthy individual who just had a CAC score CT scan done due to a family history of early heart disease. I limit my processed foods to almost 0%, but I do not always eat whole foods. My doctor wants to put me on a statin, but what can I do to help reverse or stop the arterial plaque buildup? Also, my cholesterol is consistently normal. Should I be getting checked for any gene mutations to get a better understanding of the cause?
I did my bloodwork, and my cholesterol came up super high: LDL 7.5, NON-HDL 8.2, HDL 1.35, Total Cholesterol 9.6, HDL Ratio 7.12, Triglycerides 1.68. The doctor wants to put me on statins, but at 38 years old, I don't feel comfortable with that. I've listened to many of your podcasts and experts opposing statins. I probably have Familial Hypercholesterolemia, as both my parents suffered from high cholesterol. If my CT score is not good enough, the doctor told me to start statins immediately. I know that statins can shorten life expectancy and damage cognitive brain function. However, I did an echo-radiology test, and my heart results were excellent. Should I go on statins, or should I approach a more aggressive diet/lifestyle? Are statins the only way if I am diagnosed with Familial Hypercholesterolemia?
What is the relationship between lipoprotein(a) and atherosclerosis in the episode Cholesterol, Keto Diets, and Heart Disease | Dr Spencer Nadolsky?