Vaccine Evolution Insights

The circulating vaccine-derived polio virus can evolve into a more virulent form, leading to paralysis indistinguishable from wild polio. As the risks of oral polio vaccines outweigh their benefits in many regions, there's a shift towards using mono or bivalent vaccines and the injected vaccine. While the injected vaccine provides robust immunity, it lacks the mucosal immunity that the oral vaccine offers, which is crucial for preventing transmission.