Yellow fever poses a significant risk as the ranges of Aedes mosquitoes expand, increasing the potential for outbreaks in naive human populations. The introduction of infected individuals into new areas could spark devastating epidemics, particularly in regions like Asia where yellow fever has yet to take hold. Additionally, deforestation exacerbates the issue by bringing humans into closer contact with the sylvatic cycle of the disease. Thankfully, an effective vaccine is available to help combat this looming threat.