Optimize Your Testosterone

Testosterone Types

Dr. Kyle Gillette explains the difference between total and free testosterone and their roles in the body. Total testosterone includes both bound and unbound testosterone, while free testosterone is what actually binds to androgen receptors and causes gene transcription. He uses an analogy of plumbing to describe how testosterone travels through the bloodstream and enters cells.

Free testosterone or any free androgen is what is actually binding to the receptor, and then it takes it into the nucleus of the cell, and then it binds to DNA to cause what's called gene transcription.

--- Dr. Kyle Gillette, MD

Dr. Gillette also notes that symptoms and how one feels are usually correlated more with total testosterone levels, while free testosterone is more relevant for athletic purposes 1 2.

   

Measurement Metrics

Accurate measurement of testosterone levels requires multiple tests and consideration of various metrics. Dr. Gillette emphasizes the importance of getting at least two readings to avoid outliers caused by temporary factors like poor sleep or illness. He also discusses the symptoms of low testosterone, which can range from depression and anxiety to low libido and erectile dysfunction.

It is important to get at least two readings. If you've been sick before, then maybe just postpone the blood test by a week. That way you get an accurate reading.

--- Dr. Kyle Gillette, MD

Dr. Gillette explains that testosterone levels are not as closely correlated with body composition and muscle mass as people might think 3.