Balancing Autophagy
Paul and Nora discuss the complexities of cancer initiation beyond mTOR activation, highlighting concerns about excessive autophagy and the importance of balancing anabolic and catabolic signals for optimal health.In this clip
From this podcast

Paul Saladino MD podcast
78. Is a Carnivore Diet The Real Paleo Diet? Part 2, a friendly debate with Nora Gedgaudas.
Related Questions
I'm concerned about the role of mTOR and IGF-1 in tumor growth as discussed in episode 36. AMA#2: Acid/base balance, APOE4/FTO, omega-3s, carnivore diet types, the problem with broccoli and more! and the clip Ketosis, mTOR, IGF-1. Is there a balance that can be achieved between activating these pathways for muscle growth and strength training and downregulating them through fasting? For example, could a cycle of 1 month of muscle-building weight training followed by a week of fasting help strike that balance? What might an optimal approach look like?
I have a question about the episode Dr Layne Norton: The Science of Eating for Health, Fat Loss & Lean Muscle | Huberman Lab Podcast #97 and the clip Protein and Longevity. I'm concerned about the role of mTOR and IGF-1 in tumor growth as discussed in episode 36 of the AMA#2: Acid/base balance, APOE4/FTO, omega-3s, carnivore diet types, the problem with broccoli and more! and the clip Ketosis, mTOR, IGF-1. Is there a balance that can be achieved between activating these pathways for muscle growth and strength training, and downregulating them through fasting? For example, could a cycle of 1 month of muscle-building weight training followed by a week of fasting help strike that balance? What might an optimal approach look like?
I'm concerned about the role of mTOR and IGF-1 in tumor growth as discussed in the episode 36. AMA#2: Acid/base balance, APOE4/FTO, omega-3s, carnivore diet types, the problem with broccoli and more! and clip Ketosis, mTOR, IGF-1. Is there a balance that can be achieved between activating these pathways for muscle growth and strength training, and downregulating them through fasting? For example, could a cycle of 1 month of muscle-building weight training followed by a week of fasting help strike that balance? What might an optimal approach look like?