Diet and Longevity
David shares his workout regimen and thoughts on metformin, emphasizing the importance of balancing mTOR activation for longevity. Both discuss the implications of branched chain amino acids on health, noting that caloric restriction can mitigate negative effects. The conversation highlights the significance of the methionine-glycine ratio in dietary choices, particularly in a carnivore diet that prioritizes whole animal consumption.In this clip
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Paul Saladino MD podcast
19. Can we live forever? A conversation about aging with David Sinclair PhD
Related Questions
I'm concerned about the role of mTOR and IGF-1 in tumor growth as discussed in episode 36. AMA#2: Acid/base balance, APOE4/FTO, omega-3s, carnivore diet types, the problem with broccoli and more! and the clip Ketosis, mTOR, IGF-1. Is there a balance that can be achieved between activating these pathways for muscle growth and strength training, and downregulating them through fasting? For example, could a cycle of 1 month of muscle-building weight training followed by a week of fasting help strike that balance? What might an optimal approach look like?
I'm concerned about the role of mTOR and IGF-1 in tumor growth as discussed in episode 36. AMA#2: Acid/base balance, APOE4/FTO, omega-3s, carnivore diet types, the problem with broccoli and more! and clip Ketosis, mTOR, IGF-1. Is there a balance that can be achieved between activating these pathways for muscle growth and strength training and downregulating them through fasting? For example, could a cycle of 1 month of muscle-building weight training followed by a week of fasting help strike that balance? What might an optimal approach look like?