Sleep Supplementation apigenin

Apigenin, a derivative of chamomile, is recommended by Andrew Huberman for helping with sleep. It aids in the creation of sleepiness, potentially facilitating both the initiation and continuation of sleep. Typically, a dose of 50 milligrams of apigenin can be taken to enhance sleep quality. However, Dr. Huberman warns that apigenin can act as a potent estrogen inhibitor, so it may not be suitable for individuals wanting to maintain or boost their estrogen levels. Notably, it's crucial to consult with a healthcare professional before beginning any supplementation regimen 1.

Besides its sleep-promoting attributes, apigenin increases some enzymes associated with GABA metabolism. GABA being an inhibitory neurotransmitter helps to quieten the brain activity necessary for initiating sleep 2.