What are the key benefits of NR and NMN?
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Nicotinamide Riboside (NR) and Nicotinamide Mononucleotide (NMN) are supplements known as NAD boosters. They are used to increase NAD levels in the body, which is crucial for mitochondrial function, energy production, and cellular repair. Here are some key benefits:
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Mitochondrial Function: Both NR and NMN improve mitochondrial health, which is important for energy production in cells. Increased NAD levels help in oxidizing glucose and fatty acids, thus improving energy metabolism 1 2.
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Anti-Aging and Longevity: Animal studies have shown that these supplements can enhance endurance, improve mitochondrial function, and delay aging in tissues such as liver, bones, and muscle. NR has been shown to extend lifespan when administered to older mice 2 3.
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Metabolic Health: NR supplementation can improve insulin sensitivity and counteract effects of an obesogenic diet by enhancing oxidative metabolism. This has potential benefits in staving off type 2 diabetes 2 3.
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Cognitive Benefits: Animal studies suggest that NR can enhance neurogenesis, decrease cognitive deterioration, and improve synaptic plasticity, potentially leading to better brain health 2.
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Inflammation and Muscle Health: NR has positive effects on inflammation and helps reverse muscle atrophy in animals. It's thought to enhance muscle function by increasing mitochondrial biogenesis 2 4.
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Safety and Usage: NR is considered safe for oral supplementation and has been studied in humans, showing increased NAD levels in blood with potential benefits for blood pressure and liver health. NMN has similar effects but is less studied in humans 5 4.
While these benefits are promising, especially from animal studies, further research is needed to fully understand their effects in humans. Additionally, some specific contexts, like certain cancer conditions, might show adverse effects, requiring careful consideration when using these supplements 6.
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