Is melatonin safe for long-term use?

Melatonin is generally considered safe when used in the short term and even at high doses. In one study, doses as high as 1 gram per day for a month did not show any adverse effects. Moreover, in clinical settings like the ICU, melatonin has been safely used in doses ranging from three to ten milligrams 1.

However, while melatonin is widely used and considered safe based on various studies, the long-term effects are less well understood 2. Melatonin is not heavily regulated in countries like the U.S., which complicates the ability to fully endorse its long-term safety and effectiveness. There is also a concern about the body potentially adapting to melatonin supplementation, possibly requiring higher doses over time to achieve the same effects 2.

In a clinical context, melatonin has been used to improve sleep and also shows benefits in reducing inflammation in specific diseases, but there's no evidence of categorical harm in these usages 3.

In summary, melatonin is considered safe for short-term usage and has shown no significant adverse effects in the studies conducted so far. However, due to potential adaptation and lack of regulation, cautious use is advised, particularly for long-term supplementation. Always consult healthcare professionals before beginning any supplement regimen.