What diseases are associated with LPA?

Elevated levels of Lipoprotein(a), commonly referred to as Lp(a), are associated with several diseases:

1. Atherosclerotic Cardiovascular Disease (ASCVD): Lp(a) plays a causal role in the development of ASCVD independent of LDL levels 1 2.
2. Aortic Valve Stenosis: Lp(a) is a significant risk factor for aortic valve stenosis. Elevated Lp(a) levels can initiate and accelerate the disease process, as well as increase the hazard ratio for developing this condition 1 3 4.
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     1

     LPA and Cardiovascular Risk

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     2

     LP Little A and Atherosclerotic Cardiovascular Disease

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     3

     LPA and Atherosclerosis

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     4

     LPA Pathophysiology

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3. Peripheral Artery Disease (PAD): Lp(a) is strongly associated with PAD 3.
4. Ischemic Stroke: Although Lp(a)'s association with ischemic stroke is less pronounced than with ASCVD and aortic stenosis, it is still significant. However, it is not associated with hemorrhagic strokes 3.
5. Chronic Kidney Disease: There is also an association between high Lp(a) levels and chronic kidney disease 3.

Lp(a) also contributes to inflammatory processes within the body, which exacerbates these disease conditions even in patients without established disease 3.