Twin Cycle Hypothesis
The twin cycle hypothesis explains how excess food intake over time leads to fat accumulation in the liver, causing insulin resistance. As the liver becomes less responsive to insulin, it releases more glucose into the bloodstream, prompting the pancreas to increase insulin production. This creates a vicious cycle where rising glucose levels and fat production exacerbate metabolic issues.In this clip
From this podcast

The Proof with Simon Hill
Everything you need to know about metabolic health | Metabolic Health Masterclass
Related Questions
Why does reduced insulin sensitivity lead to increased blood sugar levels? I thought the more we produce insulin, the more fat we store.
Does insulin resistance of the liver initiate metabolic syndrome?
Why does reduced insulin sensitivity lead to increased blood sugar levels in the episode Why Metabolic Dysfunction Kills with Dr. Sara Gottfried and the clip Insulin Resistance Insights? I thought the more insulin we produce, the more fat we store.