10. The ULTIMATE bloodwork podcast!

LDL & HDL

Nathan Owens and Paul Saladino explore the complexities of LDL and HDL levels, emphasizing the importance of understanding particle counts. Paul shares his lipid panel results, noting significant increases in his LDL and HDL levels after adopting a carnivore diet 1. Nathan explains the value of sophisticated lipid panels, such as nuclear magnetic resonance, which provide detailed insights into LDL particle counts and sizes 2.

   

Cholesterol Debate

The discussion continues with a debate on the atherogenic potential of LDL and HDL particles. Paul and Nathan question mainstream lipid theories, suggesting that high LDL levels may not be inherently harmful if insulin sensitivity is maintained 3. They also highlight the significance of triglycerides as a valuable marker on lipid panels, noting changes in Nathan's lipid levels after switching to a carnivore diet 4.

   

Inflammation Markers

Paul and Nathan discuss the role of oxidized LDL and other inflammation markers in cardiovascular health. They explain how oxidized LDL levels track with LDL particle counts and question the value of this marker in assessing cardiovascular risk 5. Additionally, they emphasize the importance of interpreting lipid levels within the context of inflammation and insulin resistance, recommending markers like hsCRP and myeloperoxidase for a comprehensive assessment 6.