#223: How Insulin Resistance Destroys Your Brain and Promotes Alzheimer’s and Cognitive Decline with Dr. Ben Bikman

Insulin Resistance

Insulin resistance is a growing concern, often driven by modern dietary habits. Ben Bikman explains that frequent carbohydrate consumption leads to constant spikes in blood glucose and insulin levels, which can result in insulin resistance over time 1. This chronic elevation of insulin disrupts metabolic balance, affecting various bodily functions. Stress is another significant contributor, as it can exacerbate insulin resistance, making it crucial to manage stress effectively 2.

Too much insulin drives insulin resistance. And that I can state as absolute fact, because we see this in all three relevant biomedical models.

--- Ben Bikman

Addressing these factors is essential for maintaining insulin sensitivity and preventing related health issues.

   

Brain Health

Insulin resistance has profound effects on brain health, contributing to cognitive decline and diseases like Alzheimer's. Dhru Purohit and Ben discuss how Alzheimer's is increasingly viewed as a form of "diabetes of the brain," due to its metabolic nature 3. The brain, particularly the hippocampus, struggles to utilize glucose effectively when insulin resistance is present, leading to energy deficits and cognitive impairments 4.

The hippocampus is calling out to the body almost. I know this is a silly analogy, but essentially, hey, I'm swimming in a sea of glucose, but I can't use it.

--- Ben Bikman

This highlights the importance of addressing insulin resistance to support brain function and prevent cognitive diseases.